Clinically proven to support weight loss when used alongside a healthy lifestyle, Xenical tablets are an effective treatment which is trusted worldwide.
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£ 21.99
Xenical capsules offer a unique way to lose weight. Unlike other popular products, which impact your hunger sensations and mood, this treatment works locally in the gut to block the digestion of certain dietary fats. This mechanism of action has earned Xenical the classification of a ‘peripherally acting anti-obesity agent’.
Containing 120 mg of the active ingredient orlistat, Xenical tablets have been proven to promote weight loss when taken alongside a balanced diet and regular exercise. You can also purchase the medication in its generic form or an over-the-counter version called Alli.
We’re pleased to offer Xenical weight loss tablets at the following prices:
Dispensed from a Registered UK PharmacyIt’s possible to buy Xenical in the UK once you’ve been given a prescription from a clinician or doctor. Trusted online providers such as Weight Loss Journey make this process convenient and hassle-free.
With us, you don’t need to make an appointment or worry about potentially embarrassing face-to-face consultations. Just fill out our simple online questionnaire, and our specialist team can sort everything for you.
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Xenical is a weight loss medication containing orlistat as its active ingredient. Orlistat belongs to a class of drugs called lipase inhibitors, which promote weight loss by inhibiting the digestion and absorption of dietary fats. By doing so, Xenical allows users to easily cut their calorie intake.
While other treatments such as Mounjaro and Wegovy mimic naturally occurring hormones in the brain, Xenical solely targets the digestive system. This makes it a popular alternative for people who don’t want to impact their brain chemistry or mood. The medication is most effective when used in combination with a low-fat diet and regular exercise.
Orlistat, the active ingredient in Xenical, helps people to lose weight by preventing the absorption of up to 30% of dietary fats. It does this by inhibiting the activity of lipases, digestive enzymes that break down fat molecules in the stomach and small intestine.
Under normal conditions, lipases break large fat molecules (triglycerides) into smaller ones (fatty acids and monoglycerides). These are small enough to cross the small intestine wall and enter the bloodstream, but triglycerides are not.
When you take Xenical, approximately one-third of the triglycerides entering your system remain intact. Your body can’t absorb triglycerides, so these molecules, and the calories they contain, pass through the gut and are excreted in bowel movements. In this way, orlistat can increase weight loss by about 3% compared to diet and exercise alone.
Xenical is a highly effective weight loss aid, as evidenced by numerous clinical studies. Research has shown that individuals taking Xenical can lose between 5 and 10% of their total body weight after one year of treatment. This is greater weight loss than that achieved with lifestyle modifications alone, and one large clinical trial reported that Xenical users lost almost twice as much weight as those on a placebo.
The weight loss achieved with Xenical treatment can also improve body composition, with studies reporting a decrease in visceral fat. Visceral fat surrounds the internal organs, and having large amounts of it can put you at a higher risk of cardiovascular disease. By reducing visceral fat, Xenical may, therefore, improve people’s long-term health outcomes.
Xenical may also reduce your risk of cardiovascular disease by lowering blood pressure and blood cholesterol levels. This can make it a highly beneficial treatment option for those with weight-related health conditions, and especially those at risk of heart disease.
Although Xenical can reduce your calorie intake without changes to your diet, it works best as part of a holistic weight-loss plan. For this reason, users are advised to start a low-calorie diet and an exercise regimen before beginning Xenical treatment.
Clinical trials have demonstrated that Xenical 120 mg tablets can help you lose 1-2kg in the first month. This is provided the capsules are taken consistently and as part of a healthy lifestyle. Everyone’s weight loss journey is different, so your own results may vary.
Xenical starts to work within a few days of beginning treatment. If you haven’t lost at least 5% of your body weight after three months, speak to your prescribing clinician. They may recommend that you stop taking Xenical and try a different type of weight loss medication.
Potential 5% to 10% loss of total body weight after a year of treatment.
This calculator is provided for illustrative purposes only, and the results are not guaranteed. Everyone’s weight loss journey is unique.
Starting Out
A 4-year trial of Xenical capsules found that 60% of participants lost 5% of their starting body weight within the first 12 weeks of treatment.
Steady Progress
A six-month study showed that the mean weight loss on Xenical was 4.09kg, with 19.3% of patients losing over 10kg. The majority of users noted a drop in BMI.
Sustained Results
Studies revealed that the weight loss difference between those taking Xenical capsules and those using a placebo was 3.2kg over 12 months.
Xenical is typically prescribed to people who are obese (BMI >30 kg/m2) or overweight (BMI >28 kg/m2) with weight-related health complications. Examples of these include hypertension (high blood pressure), type 2 diabetes, and sleep apnoea
Clinicians will only prescribe Xenical (orlistat) as part of a comprehensive weight management plan that includes a balanced diet, regular exercise, and behavioural modifications.
Xenical diet pills contain 120 mg of orlistat and should be taken with meals that contain fat. If you miss a meal or eat something that doesn’t contain any fat, you can skip your Xenical dose.
For the best weight loss results, it’s recommended to take Xenical tablets as part of a nutritionally balanced diet, with around 30% of calories from fat. This should be equally distributed across three meals. It’s also important to reduce your consumption of high-fat foods.
You can take Xenical tablets up to 3 times daily, with a maximum daily dose of 360 mg. Pills should be taken with water immediately before or during meals, or within one hour of eating.
Most people will take Xenical capsules for a minimum period of 12 weeks to assess their effectiveness. If they have lost at least 5% of their body weight at this point, treatment will continue.
If you miss a dose of Xenical and it has been less than an hour since your last meal containing fat, take one tablet as soon as you remember. If it's been over an hour, skip the missed dose and take the next pill as usual. There’s no additional weight loss benefit from exceeding the recommended dose of Xenical.
Xenical 120 mg capsules are usually considered safe for up to a year of use, though this can be extended as long as you continue to see the benefits. For many, the medication will become part of the long-term weight management programme. It’s essential to check in with clinicians regularly to track progress.
Although Xenical capsules are generally well tolerated, side effects can occur. This is particularly the case when taken with high-fat meals. Potential Xenical side effects include:
Oily or fatty stools
Abdominal pain
Flatulence
Blating
Rectal pain/discomfort
Sleep problems
Anxiety
Tiredness
Headaches
Dark urine
Yellowing skin
Severe stomach pain
For a more in-depth analysis of Xenical side effects, please examine the Patient Information Leaflet.
Common side effects of Xenical, such as flatulence and fatty stools, tend to settle within a few days or weeks. This is especially the case if you make better lifestyle choices like following a low-fat diet and taking regular exercise.
Most Xenical side effects will subside once your body adjusts to the treatment or your fat intake has been reduced. Eating smaller meals, drinking plenty of water, and increasing your fibre intake can also help regulate your digestion.
If you’re unsure about where to buy Xenical 120 mg capsules and what your options are, Weight Loss Journey is here to help.
Yes, you can buy Xenical weight loss pills online from a reliable supplier such as Weight Loss Journey. Just complete a short medical questionnaire, and we’ll look after the rest.
Xenical 120 mg tablets and the generic equivalent are only available by prescription in the UK, but the lower-dose Alli (60 mg) can be purchased over the counter.
Although Xenical capsules are on the NHS, access is limited. You’ll often need a higher BMI and a referral to a weight management service, which requires an appointment.
Both Xenical and Orlistat are largely considered to be the same medication. Xenical is a brand-name drug that contains 120 mg of orlistat as its active ingredient. Although Xenical is only available as 120 mg tablets, orlistat is also available as an over-the-counter 60 mg version, known as Alli.
Given their similarities, Xenical and generic Orlistat capsules are equally effective for weight loss. However, some people may prefer the branded version for its reputation. If you have questions about which medication is right for you, speak to a licensed clinician for more information.
No, Xenical does not work on burning existing fat. Instead, it supports weight loss by preventing the absorption of about 30% of the fat you eat, allowing it to pass out of the body. This makes it easier to enter into a calorie deficit, so your body can start using up previously stored fat for energy.
Diet and exercise are extremely important for Xenical weight loss. Research has shown that a healthy diet accounts for more than half of the weight loss achieved with orlistat, so making better lifestyle choices is essential to getting the most from the medication
Orlistat, the active ingredient in Xenical, is not suitable for people with chronic malabsorption syndrome or cholestasis. This is because people with these conditions already have an impaired ability to absorb dietary fat. Xenical may also be unsuitable for people with chronic kidney disease, as it can increase the risk of renal failure.
The effect of orlistat on unborn foetuses and breastfeeding babies is poorly understood. Therefore, you shouldn’t take Xenical if you are pregnant, plan to become pregnant, or are breastfeeding. Always tell your prescribing clinician about any pre-existing medical conditions before taking an orlistat-containing product.
Xenical can interact with several other medications and may decrease their efficacy. Tell your prescribing clinician if you take any of the following medications:
Ciclosporin (an immunosuppressant medication that prevents organ rejection in transplant recipients)
Acarbose (a medication used to lower blood sugar in diabetic patients)
Oral anticoagulants (drugs that prevent blood clots from forming)
Amiodarone (used to treat life-threatening heart arrhythmias)
Antiepileptic drugs (medicines used to control seizures)
You may not be able to take Xenical if it could interact with or impair the efficacy of your other medications. Speak to a healthcare professional about other potential options for weight loss treatment.
You can take Xenical with supplements, and many doctors recommend taking a multivitamin at least 2 hours before or after taking your Xenical pill. This is because orlistat affects how the body digests fat and inhibits the absorption of fat-soluble vitamins.
For this reason, Xenical users should take a daily multivitamin containing vitamins A, D, E, and K, as well as beta-carotene.
No, it’s not usually recommended to take Ozempic and Xenical together. Doing so could increase the severity of gastrointestinal side effects and lead to a great deal of discomfort. Combining both treatments may also result in nutritional deficiencies and affect the absorption of other medications. In addition, the dual effect of Ozempic and Xenical may increase insulin sensitivity, raising the risk of hypoglycemia.
It’s important to note that Ozempic is not licensed for weight loss in the UK and should only be used by patients with diabetes. Instead, Wegovy is available to help you shed the pounds and contains the same active ingredient as Ozempic (semaglutide). It is not recommended that you take Wegovy and Xenical together.
No, it is not recommended that you take Mounjaro and Xenical together. Using both medications at the same time could increase the impact of side effects and result in vitamin deficiencies. Having the right balance of nutrients is essential for losing weight safely. Combining Mounjaro and Xenical may also increase insulin sensitivity, thereby increasing the risk of hypoglycemia.
If you’re unsure which treatment is most suitable for your circumstances, our specialist clinicians can help. Simply complete our online medical questionnaire, and they will look into everything for you.
Ensure that you store Xenical tablets in their original packaging to protect them from direct sunlight and moisture, which could affect the medication. The treatment should not be exposed to temperatures above 25°C and needs to be taken before the expiry date stated on the carton. Always keep capsules out of the sight and reach of children and animals.
It’s important that you don’t dispose of medication via household waste or wastewater, as this can impact the environment
While you can drink alcohol with Xenical diet pills, it’s important to do so in moderation. Just because there is no interaction between Xenical and alcohol doesn’t mean that you should overdo it. This is due to the fact that alcohol is high in calories and could negatively impact your willpower or lead you to make unhealthy food choices.
Yes, it’s possible to switch to Xenical from other weight loss treatments like tablets or injections. You should always consult a specialist clinician before making any changes to your medication so you can be confident that the new treatment is suitable for your circumstances.
Yes, there are several alternatives to Xenical for weight loss. At Weight Loss Journey, we provide a range of treatments for you to choose from, so you’ll be able to find the right one for your circumstances. We offer:
Mounjaro: Considered one of the most effective weight loss injections, Mounjaro contains tirzepatide as its active ingredient and could lead to a drop in body weight of 22.5%.
Wegovy: A popular injection with the active ingredient semaglutide. Administered once per week, Wegovy can result in a 17% weight loss.
Nevolat: Formerly available under the brand name Saxenda, Nevolat is administered daily and may lead to a 15% drop in weight.
Orlistat: The generic form of Xenical, Orlistat capsules can achieve a similar level of weight loss and are usually cheaper than the branded version.
Alli: Available over the counter, Alli has 60 mg of orlistat and can block the absorption of up to 25% of fat.
Mysimba: Effective weight loss tablets that contain the ingredients naltrexone and bupropion. Mysimba users achieved an 8.1% weight loss after 56 weeks.
Here are some additional resources to help you learn more about Xenical (Orlistat), how it works, and clinical studies related to the drug.
MedlinePlus (2024)
FDA (1999)
PubMed (2007)
Wiley (2012)
PubMed (2017)
EMC (2023)
NHS Inform (2025)
PubMed (1998):
NICE (2025):
NIH (2024):
EMC (2023):
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Published on: 11/12/2025Reviewed on: 11/12/2025
