An over-the-counter solution, Alli diet pills could help you lose an average of 2.5kg more than relying on diet and exercise alone
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Launched in 2009, Alli is a brand name for orlistat, a weight loss medication licensed for prescription in the UK since 1998. It is available over the counter and contains 60 mg of its active ingredient. Much like their stronger counterparts Orlistat and Xenical, Alli diet pills help to block the absorption of dietary fat from meals. Because Alli works exclusively in the digestive system, it has become a popular alternative to other treatments that impact energy levels or appetite. The treatment also encourages the formation of healthy eating habits and food choices, thereby contributing to safe and sustainable weight loss.
Weight Loss Journey is pleased to offer Alli weight loss pills at the following prices
Dispensed from a Registered UK PharmacyYou can buy Alli diet pills over the counter without a prescription. However, the treatment still requires approval from a licensed clinician to determine whether it is suitable for your circumstances.
Weight Loss Journey makes this process seamless and straightforward. Simply provide some important medical information, and our experienced team will take care of the rest.
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A popular choice for people who want non-stimulant medications, Alli capsules work locally in the gut rather than impacting cravings, hunger sensations, or mood.They contain 60mg of their active ingredient and help to reduce the amount of dietary fat your body stores after every meal. Orlistat, the active ingredient in both Xenical and Alli, belongs to a class of medications called lipase inhibitors. When used as part of a holistic weight loss plan (including a low-calorie diet and regular exercise), Alli can help people lose a significant amount of weight.
Alli works by inhibiting the activity of digestive enzymes in the stomach and small intestine. It prevents these enzymes from breaking large lipid molecules (called triglycerides) down into smaller, absorbable molecules (called fatty acids and monoglycerides). Large fat molecules travel through the intestines without being absorbed into the bloodstream and are excreted from the body through bowel movements. Alli blocks the absorption of around 25% of dietary lipids, leading to a significant reduction in calories. The treatment does not work on calories gained from carbohydrates or proteins, so you should take care not to simply replace those you consume from fats with those from other food groups.
Alli pills promote weight loss by reducing the amount of fat and calories your body takes from food. Orlistat can reduce fat absorption by up to 25%, representing a significant calorie reduction for individuals on high-fat diets. However, it’s essential to note that weight loss results are most significant when Alli is used as part of a comprehensive plan.
Some studies have found that, when used in conjunction with a calorie-controlled diet, Alli can promote weight reductions of up to 5% over 16 weeks of treatment. One meta-analysis reported that people using orlistat alongside a diet and exercise plan lost an average of 2.89 kg more than those given a placebo. This suggests that Alli can produce greater weight loss than diet and exercise alone, and may be a helpful tool to boost the success of your slimming journey.
Weight reduction can have meaningful advantages for overall health, and Alli may help users realise those benefits. Research has demonstrated that using Alli can reduce visceral adipose tissue (i.e., the fat surrounding internal organs). Visceral fat is harmful to health and may even accelerate ageing, so using Alli could potentially reduce your risk of serious medical problems like metabolic and cardiovascular disease.
Alli weight loss capsules remain in the body and continue to absorb dietary fats for up to 6 hours after taking them with a fat-containing meal. If you decide to stop taking them, the tablets will stay in your system for up to 72 hours.
While Alli diet pills get to work almost immediately after consuming a meal that contains fat, it can take up to 3 months before you start noticing the full benefits of the medication. The treatment is not designed to be an immediate solution.
Potential 5.2kg weight loss after 6 months.
This calculator is provided for illustrative purposes only, and the results are not guaranteed. Everyone’s weight loss journey is unique.
This information is for illustrative purposes only. You should not use Alli for more than 6 months.
A Solid Start
Steady Progress
A 6-month study found that over 21% of participants lost at least 10% of their baseline body weight when taking Alli.
Reliable Results
Clinical trials have shown that Alli capsules can lead to a weight loss of 2.5kg more than placebo over 52 weeks*.
This information is for illustrative purposes only. You should not use Alli for more than 6 months.
Alli weight loss pills are available over the counter in the UK with no prescription required. They should be used in conjunction with a low-calorie, low-fat diet.
It’s important to complete a medical questionnaire to assess whether Alli pills are suitable for your circumstances, as they could cause adverse effects if used incorrectly or unnecessarily.
You should take Alli with water immediately before eating, or up to 1 hour after a meal. If you skip a meal or eat something that contains no fat, you don’t need to take your Alli dose. It’s also recommended to take a multivitamin each day, especially one that contains vitamins A, D, E, and K. This is because orlistat can reduce the absorption of these essential vitamins.
It’s not suitable to take Alli capsules for longer than 6 months. If you have been taking Alli for 12 weeks and haven't lost weight, speak to a healthcare professional about other treatment options. They may recommend that you stop using Alli or try a different weight-loss medication.
The treatment guidelines for Alli state that users should take one 60 mg pill three times a day before, during, or soon after a meal. You should not take more than three Alli capsules in a 24-hour period.
If you don’t eat a meal containing fat, there’s no need to take an Alli tablet. Doing so could cause side effects.
If it has been less than one hour since your last fat-containing meal, it’s safe to take your missed capsule. Should more than an hour have passed, skip the missed dose and take a tablet with your next meal.
You should not take Alli diet pills more than 3 times per day. If you exceed this amount, it’s essential to contact a doctor as soon as possible for immediate medical assistance
As with all weight loss treatments, Alli capsules may cause side effects. Most are usually mild in nature, but it’s essential to have a good idea of what you could expect. Here are some possibilities:
Flatulence (wind)
Fatty or oily stools
Soft stools
Stomach or abdominal pain
Runny/liquid stools
Anxiety
Frequent bowel movements
Incontinence (stools)
Allergic reaction
Skin blistering
Diverticulitis
Bleeding from the back passage
If you experience any of the serious Alli side effects, you should stop using the medication and seek medical help immediately. A more thorough list of symptoms can be found in the Patient Information Leaflet that comes with the treatment.
The majority of Alli side effects can be managed at home by reducing your intake of dietary fat and staying well-hydrated. It’s also important to engage in regular exercise and incorporate more fibre into your diet.
Alli side effects are usually mild and go away within the first few weeks of treatment. You may not even experience anything. Should your symptoms persist or become difficult to handle, stop taking it and consult a clinician.
Unsure about where to buy Alli in the UK and what your options are? Weight Loss Journey has all the information you need.
Yes, you can buy Alli online in the UK from reputable sources such as Weight Loss Journey. Complete our brief medical questionnaire, and we’ll take care of the rest.
No, Alli diet pills are available over the counter without a prescription. You’ll still need to provide some medical information to determine whether they’re suitable for you
No, Alli is not available on the NHS. The capsules can only be obtained from pharmacies or online weight loss consultation services such as Weight Loss Journey.
Orlistat, the active ingredient in Alli, may not be suitable for people with cholestasis, malabsorption syndrome, or those who have had an organ transplant. If any of these conditions apply to you, mention them to a licensed clinician before beginning Alli treatment.
People who are pregnant, planning to become pregnant, or breastfeeding should not take orlistat medications. Those with a history of disordered eating (such as anorexia nervosa or bulimia), and those with diabetes, kidney stones, pancreatitis, gallbladder or thyroid disease should also make their prescribing clinician aware of their medical history.
Alli may interact with other medications, and it’s important to be aware of how orlistat impacts their efficacy. For example, orlistat may reduce plasma levels of ciclosporin, an immunosuppressant used to prevent organ transplant rejection, thereby decreasing its immunosuppressive effects.
Orlistat may also change the efficacy of:
● Oral anticoagulants (like warfarin)
● Oral contraceptives
● Levothyroxine (used to treat hypothyroidism)
● Anti-epileptic medications
● Anti-retroviral medicines
● Anti-depressants
● Anti-psychotics
● Benzodiazepines
● Amiodarone (used to address heart arrhythmias)
● Acarbose (an anti-diabetes medication)
If you are taking other medications, mention these to a healthcare professional before starting Alli. They may suggest a different weight-loss treatment.
Alli does not suppress appetite. Its weight loss benefits are due to reduced fat absorption, rather than a reduced desire to eat. This is why doctors recommend that users start a diet and exercise plan prior to commencing Alli treatment.
Unabsorbed dietary fat exits the body in bowel movements. If you eat a high-fat diet on Alli, you may experience increased gastrointestinal side effects such as wind, diarrhoea, and smelly stools. Most people find that these symptoms are reduced by adherence to a low-fat diet.
Alli is not recommended for pregnant people. Doctors don’t know if orlistat can be secreted in breast milk, so it should not be used by breastfeeding people, either. If you are pregnant, planning to become pregnant, or breastfeeding, speak to a licensed clinician about alternative weight loss treatment options.
No, it’s not recommended to take 2 Alli tablets instead of 1 Xenical. While Alli contains half the amount of its active ingredient (orlistat) as Xenical, the latter reduces fat absorption by only 5% more. This could result in more severe side effects for very little gain.
Taking a higher dose of Alli than is necessary could be classified as an overdose and is potentially dangerous. It’s essential that you always stick to the medically approved dosage schedule to ensure the safety of the treatment.
Alli diet pills should be stored at temperatures below 25℃, away from harsh light and humidity. The capsules come in a bottle that contains two silica gel canisters to keep them dry. Do not remove the canisters from the bottle or swallow them. Keep the medication out of the sight and reach of children and animals, and do not consume them after the expiry date.
Yes, you can drink alcohol while taking Alli, though it’s recommended to only do so in moderation. Despite there being no interaction between Alli and alcohol, excessive drinking can increase the risk and severity of side effects. Alcohol is also a source of empty calories, which can negatively impact your weight loss
Yes, it’s possible to change to Alli from other weight loss treatments, no matter if they are in tablet or injection form. You should always consult a doctor or clinician before making the switch, as they will advise you on the safest way to stop your current treatment and move to Alli.
Yes, there are alternatives to Alli for weight loss. However, they are all classified as prescription-only medications (POMs) and are not available over the counter. At Weight Loss Journey, we offer the following treatments:
Mounjaro: A once-weekly weight loss injection that contains the dual-action active ingredient tirzepatide. Clinical trials have shown that Mounjaro can lead to a loss of 20.9% of body weight after 36 weeks.
Wegovy: Containing the active ingredient semaglutide, Wegovy is a highly effective injection. Studies have found that over half of patients using the treatment could lose at least 15% of their starting body weight.
Nevolat: Unlike other weight loss injections, Nevolat is administered once per day. In one clinical trial, over 67% of people achieved at least a 5% weight loss after just 12 weeks of treatment. Nevolat contains the active ingredient liraglutide.
Xenical: Taken up to 3 times daily with a fat-containing meal, Xenical capsules block the absorption of approximately 30% of dietary fat , thereby facilitating a calorie deficit.
Orlistat: The generic form of Xenical. Clinical trials showed that patients taking Orlistat lost 2.89kg more weight than those using a placebo.
Mysimba: Originally licensed to combat addiction, the dual active ingredients in Mysimba tablets could result in a 3.67kg reduction in body weight.
Here are some additional resources to help you learn more about Mounjaro, how it works, and clinical studies related to the drug.
UK Government (2014)
MedlinePlus (2024):
EMA (2024):
Annals of Internal Medicine (2005):
Wiley (2012):
Imperial College London (2025):
EMC (2023):
Royal Pharmaceutical Society (2025):
EMC:
NHS (2022):
NICE (2025):
Springer Nature (2024):
Weight Loss Journey is proud to offer a variety of treatments to help you reach your goals
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Published on: 11/12/2025Reviewed on: 11/12/2025
